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Antibiotic and other pharma-cologically active substances

The amount of antibiotic mentioned in column (2), on the sea foods including shrimps, prawns or any other variety of fish and fishery products, shall not exceed the tolerance limit prescribed in column (3) of the table given below:—

Name of Antibiotics Tolerance limit mg/kg (ppm)
Tetracycline 0.1
Oxytetracycline 0.1
Trimethoprim 0.005
Oxolinic acid 0.3

The use of any of the following antibiotics and other Pharmacologically Active Substances shall be prohibited in any unit processing sea foods including shrimps, prawns or any other variety of fish and fishery products —
(i) All Nitrofurans including
(ii) Furaltadone
(iii) Furazolidone (iv) Furylfuramide
(v) Nifuratel
(vi) Nifuroxime
(vii) Nifurprazine
(viii) Nitrofurnatoin
(ix) Nitrofurazone
(x) Chloramphenicol
(xi) Neomycin
(xii) Nalidixic acid
(xiii) Sulphamethoxazole
(xiv) Aristolochia spp and preparations thereof
(xv) Chloroform
(xvi) Chloropromazine
(xvii) Cholchicine
(xviii) Dapsone
(xix) Dimetridazole
(xx) Metronidazole
(xxi) Ronidazole
(xxii) Ipronidazole
(xxiii) Other nitromidazoles
(xxiv) Clenbuterol
(xxv) Diethylstibestrol (DES)
(xxvi) Sulfanoamide drugs (except approved Sulfadimethoxine, Sulfabromomethazine and Sulfaethoxypyridazine)
(xxvii) Fluoroquinolones
(xxviii) Glycopeptides.
The limit of antibiotics mentioned in column (2) , in honey on the basis of Limit of Quantification, Shall not exceed the limit of quantification , shall not exceed the tolerance limit prescribed in column (3) when determined by the LC-MS/MS method in the table given below :


Name of Antibiotics Tolerance limit mg/kg (ppm)
Chloramphenicol 0.3*
Nitrofurans and its metabolites 0.5* (Either individually or collectively)
Sulphonamides and its metabolites 5.0* (Either individually or collectively)
Streptomycin 5.0*
Tetracycline 5.0*
(a) Oxytetracycline 5.0*
(b) Chlortetracycline 5.0*
Ampicillin 5.0*
Enrofloxacin 5.0*
Ciprofloxacin 5.0*
Erythromycin 5.0*
Tylosin 5.0*
*Limit of Quantification on the basis of LC-MS/MS method".